Activation of mTORC1 in collecting ducts causes hyperkalemia

Z Chen, H Dong, C Jia, Q Song, J Chen… - Journal of the …, 2014 - journals.lww.com
Mutation of TSC (encoding tuberous sclerosis complex protein) and activation of mammalian
target of rapamycin (mTOR) have been implicated in the pathogenesis of several renal
diseases, such as diabetic nephropathy and polycystic kidney disease. However, the role of
mTOR in renal potassium excretion and hyperkalemia is not known. We showed that mice
with collecting-duct (CD)–specific ablation of TSC1 (CDTsc1KO) had greater mTOR complex
1 (mTORC1) activation in the CD and demonstrated features of pseudohypoaldosteronism …