Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia
K Keeshan, O Shestova, LS Ussin, WS Pear - Blood Cells, Molecules, and …, 2008 - Elsevier
Trib2 is a member of the Trib family of serine/threonine kinase-like proteins (Trib1, Trib2,
Trib3). Mice reconstituted with hematopoietic stem cells (HSC) retrovirally expressing Trib2
uniformly developed fatal transplantable acute myelogenous leukemia (AML). Trib2-induced
AML was clonal and we sought to identify cooperating genes in Trib2-induced AML. Using
Splinkerette PCR techniques, we identified proviral insertion near HoxA9 in a Trib2
monoclonal tumor, which resulted in greatly elevated HoxA9 expression. Mice reconstituted …
Trib3). Mice reconstituted with hematopoietic stem cells (HSC) retrovirally expressing Trib2
uniformly developed fatal transplantable acute myelogenous leukemia (AML). Trib2-induced
AML was clonal and we sought to identify cooperating genes in Trib2-induced AML. Using
Splinkerette PCR techniques, we identified proviral insertion near HoxA9 in a Trib2
monoclonal tumor, which resulted in greatly elevated HoxA9 expression. Mice reconstituted …
