Error-prone DNA repair and translesion DNA synthesis: II: The inducible SOS hypothesis
BA Bridges - DNA repair, 2005 - Elsevier
Evelyn Witkin hypothesized in 1967 that bacterial cell division is controlled by a repressor
which, like the lambda repressor, is inactivated by a complex process that starts with the
presence of replication-blocking lesions in the DNA. She further suggested that this might
not be the only cellular function to show induction by DNA damage. Three years later,
Miroslav Radman, in a privately circulated note, proposed that one such function might be
an inaccurate (mutation-prone) DNA polymerase under the control of the recA and lexA …
which, like the lambda repressor, is inactivated by a complex process that starts with the
presence of replication-blocking lesions in the DNA. She further suggested that this might
not be the only cellular function to show induction by DNA damage. Three years later,
Miroslav Radman, in a privately circulated note, proposed that one such function might be
an inaccurate (mutation-prone) DNA polymerase under the control of the recA and lexA …
