The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers
NS Baranova, E Nilebäck, FM Haller, DC Briggs… - Journal of Biological …, 2011 - ASBMB
Tumor necrosis factor-stimulated gene-6 (TSG-6) is a hyaluronan (HA)-binding protein that
plays important roles in inflammation and ovulation. TSG-6-mediated cross-linking of HA has
been proposed as a functional mechanism (eg for regulating leukocyte adhesion), but direct
evidence for cross-linking is lacking, and we know very little about its impact on HA
ultrastructure. Here we used films of polymeric and oligomeric HA chains, end-grafted to a
solid support, and a combination of surface-sensitive biophysical techniques to quantify the …
plays important roles in inflammation and ovulation. TSG-6-mediated cross-linking of HA has
been proposed as a functional mechanism (eg for regulating leukocyte adhesion), but direct
evidence for cross-linking is lacking, and we know very little about its impact on HA
ultrastructure. Here we used films of polymeric and oligomeric HA chains, end-grafted to a
solid support, and a combination of surface-sensitive biophysical techniques to quantify the …
