[HTML][HTML] Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells
M Qadura, M Othman, B Waters, R Chegeni… - Journal of thrombosis …, 2008 - Elsevier
Background: The development of neutralizing antibodies to factor FVIII (FVIII) represents the
most serious complication in the treatment of hemophilia A. Objective: We have explored the
potential of using immature dendritic cells (iDCs) to present FVIII in a tolerogenic manner to
T cells. Methods: The iDCs were isolated from hemophilic murine bone marrow and pulsed
with canine cFVIII (cFVIII‐iDCs) in the presence or absence of the NFκB pathway blocking
compound Andrographolide (Andro‐cFVIII‐iDCs). Three weekly intravenous infusions of …
most serious complication in the treatment of hemophilia A. Objective: We have explored the
potential of using immature dendritic cells (iDCs) to present FVIII in a tolerogenic manner to
T cells. Methods: The iDCs were isolated from hemophilic murine bone marrow and pulsed
with canine cFVIII (cFVIII‐iDCs) in the presence or absence of the NFκB pathway blocking
compound Andrographolide (Andro‐cFVIII‐iDCs). Three weekly intravenous infusions of …