[HTML][HTML] A critical period in the supraspinal control of pain: opioid-dependent changes in brainstem rostroventral medulla function in preadolescence
GJ Hathway, D Vega-Avelaira, M Fitzgerald - PAIN®, 2012 - Elsevier
We have previously shown that the balance of electrically evoked descending brainstem
control of spinal nociceptive reflexes undergoes a switch from excitation to inhibition in
preadolescent rats. Here we show that the same developmental switch occurs when μ-
opioid receptor agonists are microinjected into the rostroventral medulla (RVM).
Microinjections of the μ-opioid receptor agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin
(DAMGO) into the RVM of lightly anaesthetised adult rats produced a dose-dependent …
control of spinal nociceptive reflexes undergoes a switch from excitation to inhibition in
preadolescent rats. Here we show that the same developmental switch occurs when μ-
opioid receptor agonists are microinjected into the rostroventral medulla (RVM).
Microinjections of the μ-opioid receptor agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin
(DAMGO) into the RVM of lightly anaesthetised adult rats produced a dose-dependent …