Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy
S Gately, WW Li - Seminars in Oncology, 2004 - Elsevier
Angiogenesis is required for multistage carcinogenesis. The inducible enzyme
cyclooxygenase-2 (COX-2) is an important mediator of angiogenesis and tumor growth.
COX-2 expression occurs in a wide range of preneoplastic and malignant conditions; and
the enzyme has been localized to the neoplastic cells, endothelial cells, immune cells, and
stromal fibroblasts within tumors. The proangiogenic effects of COX-2 are mediated primarily
by three products of arachidonic metabolism: thromboxane A2 (TXA2), prostaglandin E2 …
cyclooxygenase-2 (COX-2) is an important mediator of angiogenesis and tumor growth.
COX-2 expression occurs in a wide range of preneoplastic and malignant conditions; and
the enzyme has been localized to the neoplastic cells, endothelial cells, immune cells, and
stromal fibroblasts within tumors. The proangiogenic effects of COX-2 are mediated primarily
by three products of arachidonic metabolism: thromboxane A2 (TXA2), prostaglandin E2 …