Prophylactic effects of prostaglandin E2 on NSAID-induced enteropathy—role of EP4 receptors in its protective and healing-promoting effects
K Takeuchi - Current opinion in pharmacology, 2014 - Elsevier
Highlights•NSAID-induced enteropathy was prevented by PGE 2 via the activation of EP4
receptors.•The protection occurred with increase of mucus secretion and inhibition of
motility.•These changes led to the inhibition of enterobacterial invasion and iNOS
expression.•The healing of these lesions was promoted by PGE 2 and impaired by the EP4
antagonist.•PGE 2 stimulated angiogenesis by up-regulating VEGF expression via EP4
receptors.Prostaglandin E 2 not only prevents NSAID-generated small intestinal lesions, but …
receptors.•The protection occurred with increase of mucus secretion and inhibition of
motility.•These changes led to the inhibition of enterobacterial invasion and iNOS
expression.•The healing of these lesions was promoted by PGE 2 and impaired by the EP4
antagonist.•PGE 2 stimulated angiogenesis by up-regulating VEGF expression via EP4
receptors.Prostaglandin E 2 not only prevents NSAID-generated small intestinal lesions, but …