An ulcer is a deep necrotic lesion penetrating through the entire thickness of the
gastrointestinal mucosa and muscularis mucosae. Ulcer healing is a complex and tightly
regulated process of filling the mucosal defect with proliferating and migrating epithelial and
connective tissue cells. This process includes the re-establishment of the continuous surface
epithelial layer, glandular epithelial structures, microvessels and connective tissue within the
scar. Epithelial cells in the mucosa of the ulcer margin proliferate and migrate onto the …