Regulation of WNK1 expression by miR-192 and aldosterone
E Elvira-Matelot, X Zhou, N Farman… - Journal of the …, 2010 - journals.lww.com
WNK1 and WNK4 encode two members of the WNK serine-threonine kinase subfamily.
Greater WNK1 expression associates with higher BP. A combination of promoters,
enhancers, repressors, and insulators regulate WNK1 expression, but whether microRNAs
also modulate WNK1 expression is unknown. Here, computational analysis revealed the
presence of a target sequence for miR-192 and miR-215 at the same site in the 3′
untranslated region of the ubiquitous L-and the kidney-specific KS-WNK1. We functionally …
Greater WNK1 expression associates with higher BP. A combination of promoters,
enhancers, repressors, and insulators regulate WNK1 expression, but whether microRNAs
also modulate WNK1 expression is unknown. Here, computational analysis revealed the
presence of a target sequence for miR-192 and miR-215 at the same site in the 3′
untranslated region of the ubiquitous L-and the kidney-specific KS-WNK1. We functionally …