[HTML][HTML] The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced …
T Tohmonda, M Yoda, H Mizuochi, H Morioka… - Journal of Biological …, 2013 - ASBMB
To address the" endoplasmic reticulum stress" triggered by the burden of protein synthesis,
the unfolded protein response is induced during osteoblast differentiation. In this study, we
show that the transcription of parathyroid hormone (PTH)/PTH-related peptide receptor
(PTH1R) is regulated by one of the endoplasmic reticulum-stress mediators, the IRE1α-
XBP1 pathway, in osteoblasts. We found that the increase in Pth1r transcription upon BMP2
treatment is significantly suppressed in mouse embryonic fibroblasts lacking IRE1α. As …
the unfolded protein response is induced during osteoblast differentiation. In this study, we
show that the transcription of parathyroid hormone (PTH)/PTH-related peptide receptor
(PTH1R) is regulated by one of the endoplasmic reticulum-stress mediators, the IRE1α-
XBP1 pathway, in osteoblasts. We found that the increase in Pth1r transcription upon BMP2
treatment is significantly suppressed in mouse embryonic fibroblasts lacking IRE1α. As …