Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue
LC Chang, CW Fan, WK Tseng, JR Chen… - Applied …, 2013 - journals.lww.com
Oxidative stress is a contributing factor in the carcinogenesis of colorectal cancer. The Nrf2
[nuclear factor (erythroid-derived 2)-like 2; NFE2L2] pathway is one of the major cellular
defense mechanisms against oxidative stress. This study investigated the expression of the
Nrf2 pathway in colorectal cancer. Formalin-fixed paraffin-embedded tissue arrays
consisting of the tumor, adjacent normal, and distant normal tissues from the resected
specimens of 83 colorectal cancer patients were subjected to immunohistochemical (IHC) …
[nuclear factor (erythroid-derived 2)-like 2; NFE2L2] pathway is one of the major cellular
defense mechanisms against oxidative stress. This study investigated the expression of the
Nrf2 pathway in colorectal cancer. Formalin-fixed paraffin-embedded tissue arrays
consisting of the tumor, adjacent normal, and distant normal tissues from the resected
specimens of 83 colorectal cancer patients were subjected to immunohistochemical (IHC) …
