Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs
U Goebel, M Siepe, A Mecklenburg, P Stein… - The Journal of the …, 2008 - pubs.asahq.org
Background Cardiopulmonary bypass (CPB) is associated with pulmonary inflammation and
dysfunction. This may lead to acute lung injury and acute respiratory distress syndrome with
increased morbidity and mortality. The authors hypothesized that inhaled carbon monoxide
before initiation of CPB would reduce inflammatory response in the lungs. Methods In a
porcine model, a beating-heart CPB was used. The animals were either randomized to a
control group, to standard CPB, or to CPB plus carbon monoxide. In the latter group, lungs …
dysfunction. This may lead to acute lung injury and acute respiratory distress syndrome with
increased morbidity and mortality. The authors hypothesized that inhaled carbon monoxide
before initiation of CPB would reduce inflammatory response in the lungs. Methods In a
porcine model, a beating-heart CPB was used. The animals were either randomized to a
control group, to standard CPB, or to CPB plus carbon monoxide. In the latter group, lungs …
