Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney
R Kojima, T Sekine, M Kawachi, SH Cha… - Journal of the …, 2002 - journals.lww.com
Recently, a family of multispecific organic anion transporters has been identified, and
several isoforms have been reported. However, the physiologic and pharmacologic roles of
each isoform, except OAT1, in the transepithelial transport of organic anions in the kidney
remain to be elucidated. To address this issue, it is essential to determine the intrarenal
distribution and membrane localization of each OAT isoform along the nephron. In this study,
the intrarenal distributions of rOAT1, rOAT2, and rOAT3 were investigated by an …
several isoforms have been reported. However, the physiologic and pharmacologic roles of
each isoform, except OAT1, in the transepithelial transport of organic anions in the kidney
remain to be elucidated. To address this issue, it is essential to determine the intrarenal
distribution and membrane localization of each OAT isoform along the nephron. In this study,
the intrarenal distributions of rOAT1, rOAT2, and rOAT3 were investigated by an …