Epithelial sodium channel (ENaC) and the control of blood pressure
BC Rossier - Current opinion in pharmacology, 2014 - Elsevier
Highlights•Genetic dissection of ENaC mediated sodium transport validate novel drug
targets.•Signaling pathways controlling ENaC activity identifies novel drug targets.•
Phamacodynamic and pharmacokinetics properties of next generation diuretics.The
amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for
sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal
colon, the duct of several exocrine glands, and the lung. The activity of this channel is …
targets.•Signaling pathways controlling ENaC activity identifies novel drug targets.•
Phamacodynamic and pharmacokinetics properties of next generation diuretics.The
amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for
sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal
colon, the duct of several exocrine glands, and the lung. The activity of this channel is …