[HTML][HTML] Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways
A Sakakibara, S Hattori - Journal of Biological Chemistry, 2000 - ASBMB
Cas (Crk-associatedsubstrate) and HEF1 (human enhancer of filamentation) are related
adaptor proteins that function in integrin-mediated cell adhesion and antigen receptor
signaling pathways. We report here a molecular cloning of Chat (Cas/HEF1-associated
signaltransducer) that associates with Cas and HEF1. Chat is a 78-kDa signaling molecule
with an N-terminal SH2 domain and is expressed in a wide range of tissues. In
hematopoietic cells, a 115-kDa isoform of Chat (Chat-H) was specifically expressed. Chat is …
adaptor proteins that function in integrin-mediated cell adhesion and antigen receptor
signaling pathways. We report here a molecular cloning of Chat (Cas/HEF1-associated
signaltransducer) that associates with Cas and HEF1. Chat is a 78-kDa signaling molecule
with an N-terminal SH2 domain and is expressed in a wide range of tissues. In
hematopoietic cells, a 115-kDa isoform of Chat (Chat-H) was specifically expressed. Chat is …