[HTML][HTML] Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504
T Ichiba, Y Hashimoto, M Nakaya, Y Kuraishi… - Journal of Biological …, 1999 - ASBMB
C3G is a guanine nucleotide exchange factor for Rap1 and is activated by the expression of
Crk adaptor proteins. We found that expression of CrkI in COS cells induced significant
tyrosine phosphorylation of C3G. To understand the mechanism by which C3G is
phosphorylated and activated by Crk, we constructed a series of deletion mutants. Deletion
of the amino terminus of C3G to amino acid 61 did not remarkably affect either tyrosine
phosphorylation or Crk-dependent activation of C3G. When C3G was truncated to amino …
Crk adaptor proteins. We found that expression of CrkI in COS cells induced significant
tyrosine phosphorylation of C3G. To understand the mechanism by which C3G is
phosphorylated and activated by Crk, we constructed a series of deletion mutants. Deletion
of the amino terminus of C3G to amino acid 61 did not remarkably affect either tyrosine
phosphorylation or Crk-dependent activation of C3G. When C3G was truncated to amino …