Negative selection imparts peptide specificity to the mature T cell repertoire
ES Huseby, F Crawford, J White… - Proceedings of the …, 2003 - National Acad Sciences
ES Huseby, F Crawford, J White, J Kappler, P Marrack
Proceedings of the National Academy of Sciences, 2003•National Acad SciencesThe T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins
encoded in the MHC. The MHC portion of this complex contributes much to the footprint of
the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides.
Here, we show that the development of peptide-specific T cells is not intrinsic to thymocytes
that undergo thymic-positive selection but is an outcome of eliminating, through negative
selection, thymocytes bearing TCRs with extensive peptide cross-reactivity. Hence, thymic …
encoded in the MHC. The MHC portion of this complex contributes much to the footprint of
the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides.
Here, we show that the development of peptide-specific T cells is not intrinsic to thymocytes
that undergo thymic-positive selection but is an outcome of eliminating, through negative
selection, thymocytes bearing TCRs with extensive peptide cross-reactivity. Hence, thymic …
The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development of peptide-specific T cells is not intrinsic to thymocytes that undergo thymic-positive selection but is an outcome of eliminating, through negative selection, thymocytes bearing TCRs with extensive peptide cross-reactivity. Hence, thymic-negative selection imposes peptide specificity on the mature T cell repertoire.
National Acad Sciences
