Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice
T Vanwolleghem, L Libbrecht, BE Hansen… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: The human liver-uPA+/+-SCID mouse is currently the best small
animal model available for viral hepatitis infection studies. METHODS: We identify critical
factors affecting animal survival, engraftment efficacy, kinetics of liver repopulation and
virological outcome by analysing the data from 400 human hepatocyte transplantations and
115 subsequent HBV and/or HCV inoculations in this mouse model. RESULTS: Almost one
third of animals succumbed during the first week after hepatocyte transplantation. Only …
animal model available for viral hepatitis infection studies. METHODS: We identify critical
factors affecting animal survival, engraftment efficacy, kinetics of liver repopulation and
virological outcome by analysing the data from 400 human hepatocyte transplantations and
115 subsequent HBV and/or HCV inoculations in this mouse model. RESULTS: Almost one
third of animals succumbed during the first week after hepatocyte transplantation. Only …