[PDF][PDF] TP53 Mutations and Outcome in Osteosarcoma: A Prospective, Multicenter Study
JS Wunder, N Gokgoz, R Parkes, SB Bull… - Journal of Clinical …, 2005 - academia.edu
JS Wunder, N Gokgoz, R Parkes, SB Bull, S Eskandarian, AM Davis, CP Beauchamp…
Journal of Clinical Oncology, 2005•academia.eduPurpose Mutations of the TP53 gene have been associated with resistance to chemotherapy
as well as poor prognosis in many different malignancies. This is the first prospective study
of the prognostic value of somatic TP53 mutations in patients with newly diagnosed
extremity osteosarcoma.
as well as poor prognosis in many different malignancies. This is the first prospective study
of the prognostic value of somatic TP53 mutations in patients with newly diagnosed
extremity osteosarcoma.
Purpose
Mutations of the TP53 gene have been associated with resistance to chemotherapy as well as poor prognosis in many different malignancies. This is the first prospective study of the prognostic value of somatic TP53 mutations in patients with newly diagnosed extremity osteosarcoma.
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