Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes
M Sharma, F Urano, A Jaeschke - Journal of hepatology, 2012 - Elsevier
BACKGROUND & AIMS: Saturated free fatty acid (SFA)-stimulated c-Jun NH2-terminal
kinase (JNK) activation is associated with the pathogenesis of non-alcoholic fatty liver
disease (NAFLD). However, the mechanisms responsible for the effects of SFA are
incompletely understood. The goal of this study was to determine the molecular mechanisms
by which SFA induce JNK activation in hepatocytes. METHODS: We used siRNA-mediated
knockdown in Hepa1c1c7 and AML12 cell lines, as well as primary mouse hepatocytes for …
kinase (JNK) activation is associated with the pathogenesis of non-alcoholic fatty liver
disease (NAFLD). However, the mechanisms responsible for the effects of SFA are
incompletely understood. The goal of this study was to determine the molecular mechanisms
by which SFA induce JNK activation in hepatocytes. METHODS: We used siRNA-mediated
knockdown in Hepa1c1c7 and AML12 cell lines, as well as primary mouse hepatocytes for …
