[HTML][HTML] The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase
AS Marsin, C Bouzin, L Bertrand, L Hue - Journal of Biological Chemistry, 2002 - ASBMB
The activation of monocytes involves a stimulation of glycolysis, release of potent
inflammatory mediators, and alterations in gene expression. All of these processes are
known to be further increased under hypoxic conditions. The activated monocytes express
inducible 6-phosphofructo-2-kinase (iPFK-2), which synthesizes fructose 2, 6-bisphosphate,
a stimulator of glycolysis. During ischemia, AMP-activated protein kinase (AMPK) activates
the homologous heart 6-phosphofructo-2-kinase isoform by phosphorylating its Ser-466 …
inflammatory mediators, and alterations in gene expression. All of these processes are
known to be further increased under hypoxic conditions. The activated monocytes express
inducible 6-phosphofructo-2-kinase (iPFK-2), which synthesizes fructose 2, 6-bisphosphate,
a stimulator of glycolysis. During ischemia, AMP-activated protein kinase (AMPK) activates
the homologous heart 6-phosphofructo-2-kinase isoform by phosphorylating its Ser-466 …
