Reduced podocyte expression of α3β1 integrins and podocyte depletion in patients with primary focal segmental glomerulosclerosis and chronic PAN-treated rats
CA Chen, JC Hwang, JY Guh, JM Chang, YH Lai… - Journal of Laboratory …, 2006 - Elsevier
Integrins attach cells to extracellular matrix (ECM) and mediate signals from ECM to cells or
from cells to ECM. They regulate cell functions, including adhesion, migration, cell cycle
regulation, and differentiation. Podocytes may detach from the glomerular basement
membrane (GBM) and be excreted in the urine, and proteinuria is found in patients with
primary focal segmental glomerulosclerosis (FSGS); both may be associated with loss of
α3β1integrins. In this study, we have examined the podocyte number in patients with primary …
from cells to ECM. They regulate cell functions, including adhesion, migration, cell cycle
regulation, and differentiation. Podocytes may detach from the glomerular basement
membrane (GBM) and be excreted in the urine, and proteinuria is found in patients with
primary focal segmental glomerulosclerosis (FSGS); both may be associated with loss of
α3β1integrins. In this study, we have examined the podocyte number in patients with primary …