[HTML][HTML] Caveolin-1 assembles type 1 inositol 1, 4, 5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex …
A Adebiyi, D Narayanan, JH Jaggar - Journal of biological chemistry, 2011 - ASBMB
Physical coupling of sarcoplasmic reticulum (SR) type 1 inositol 1, 4, 5-trisphosphate
receptors (IP 3 R1) to plasma membrane canonical transient receptor potential 3 (TRPC3)
channels activates a cation current (I Cat) in arterial smooth muscle cells that induces
vasoconstriction. However, structural components that enable IP 3 R1 and TRPC3 channels
to communicate locally are unclear. Caveolae are plasma membrane microdomains that can
compartmentalize proteins. Here, we tested the hypothesis that caveolae and specifically …
receptors (IP 3 R1) to plasma membrane canonical transient receptor potential 3 (TRPC3)
channels activates a cation current (I Cat) in arterial smooth muscle cells that induces
vasoconstriction. However, structural components that enable IP 3 R1 and TRPC3 channels
to communicate locally are unclear. Caveolae are plasma membrane microdomains that can
compartmentalize proteins. Here, we tested the hypothesis that caveolae and specifically …