Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation
E Ozcan, I Rauter, L Garibyan, SR Dillon… - Journal of allergy and …, 2011 - Elsevier
BACKGROUND: B cells receive activating signals from T cells through CD40, from microbial
DNA through Toll-like receptor (TLR) 9, and from dendritic cells through transmembrane
activator and calcium-modulating cyclophilin ligand interactor (TACI). TLR9 and CD40
ligation augment TACI-driven B-cell activation, but only the mechanism of synergy between
CD40 and TACI has been explored. Synergy between CD40 and TLR9 in B-cell activation is
controversial. OBJECTIVE: We sought to examine the mechanisms by which TLR9 …
DNA through Toll-like receptor (TLR) 9, and from dendritic cells through transmembrane
activator and calcium-modulating cyclophilin ligand interactor (TACI). TLR9 and CD40
ligation augment TACI-driven B-cell activation, but only the mechanism of synergy between
CD40 and TACI has been explored. Synergy between CD40 and TLR9 in B-cell activation is
controversial. OBJECTIVE: We sought to examine the mechanisms by which TLR9 …
