The role of transforming growth factor β1 in the vascular system
The transforming growth factor β (TGFβ) family of cytokines exert pleiotropic effects upon a
wide variety of cell types. TGFβ1 has been demonstrated to be of fundamental importance in
the development, physiology and pathology of the vascular system. As the role of TGFβ1 in
these processes becomes clearer, influencing its activity for therapeutic benefit is now
beginning to be investigated. This review presents an overview of the role of TGFβ1 in the
vasculature. The cellular and extracellular biology of the TGFβ family is first addressed …
wide variety of cell types. TGFβ1 has been demonstrated to be of fundamental importance in
the development, physiology and pathology of the vascular system. As the role of TGFβ1 in
these processes becomes clearer, influencing its activity for therapeutic benefit is now
beginning to be investigated. This review presents an overview of the role of TGFβ1 in the
vasculature. The cellular and extracellular biology of the TGFβ family is first addressed …
