Defects in cell growth regulation by C18: 0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas
S Koybasi, CE Senkal, K Sundararaj… - Journal of Biological …, 2004 - ASBMB
In this study, endogenous long chain ceramides were measured in 32 human head and
neck squamous cell carcinoma (HNSCC) and 10 nonsquamous head and neck carcinoma
tumor tissues, as compared with adjacent noncancerous tissues, by liquid
chromatography/mass spectroscopy. Interestingly, only one specific ceramide, C 18: 0-
ceramide, was selectively down-regulated in the majority of HNSCC tumor tissues. On the
other hand, in nonsquamous tumor tissues, this selectivity for C 18-ceramide was not …
neck squamous cell carcinoma (HNSCC) and 10 nonsquamous head and neck carcinoma
tumor tissues, as compared with adjacent noncancerous tissues, by liquid
chromatography/mass spectroscopy. Interestingly, only one specific ceramide, C 18: 0-
ceramide, was selectively down-regulated in the majority of HNSCC tumor tissues. On the
other hand, in nonsquamous tumor tissues, this selectivity for C 18-ceramide was not …
