A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation
W Meissner, P Leyendecker, S Mueller-Lissner… - European Journal of …, 2009 - Elsevier
BACKGROUND: Opioid-induced constipation can have a major negative impact on patients'
quality of life. This randomised, double-blinded study evaluated the analgesic efficacy of
prolonged-release (PR) oral oxycodone when co-administered with PR oral naloxone, and
its impact on opioid-induced constipation in patients with severe chronic pain. Another
objective was to identify the optimal dose ratio of oxycodone and naloxone. METHODS: A
total of 202 patients with chronic pain (mainly non-cancer related, 2.5% of patients had …
quality of life. This randomised, double-blinded study evaluated the analgesic efficacy of
prolonged-release (PR) oral oxycodone when co-administered with PR oral naloxone, and
its impact on opioid-induced constipation in patients with severe chronic pain. Another
objective was to identify the optimal dose ratio of oxycodone and naloxone. METHODS: A
total of 202 patients with chronic pain (mainly non-cancer related, 2.5% of patients had …
