[HTML][HTML] Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase
F Liang, Y Luo, Y Dong, CD Walls, J Liang… - Journal of biological …, 2008 - ASBMB
Phosphatase of regenerating liver 3 (PRL3) is up-regulated in cancer metastases. However,
little is known of PRL3-mediated cellular signaling pathways. We previously reported that
elevated PRL3 expression increases Src kinase activity, which likely contributes to the
increased tumorigenesis and metastasis potential of PRL3. PRL3-induced Src activation is
proposed to be indirect through down-regulation of Csk, a negative regulator of Src. Given
the importance of PRL3 in tumor metastasis and the role of Csk in controlling Src activity, we …
little is known of PRL3-mediated cellular signaling pathways. We previously reported that
elevated PRL3 expression increases Src kinase activity, which likely contributes to the
increased tumorigenesis and metastasis potential of PRL3. PRL3-induced Src activation is
proposed to be indirect through down-regulation of Csk, a negative regulator of Src. Given
the importance of PRL3 in tumor metastasis and the role of Csk in controlling Src activity, we …
