[PDF][PDF] Hypoxia signaling in hematopoietic stem cells: a double-edged sword
PJ Pollard, KR Kranc - Cell Stem Cell, 2010 - cell.com
PJ Pollard, KR Kranc
Cell Stem Cell, 2010•cell.comAlthough hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of
hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et
al.(2010) and Simsek et al.(2010) demonstrate that hypoxia regulates the metabolic state of
HSCs and protects their integrity by controlling HIF-1α.
hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et
al.(2010) and Simsek et al.(2010) demonstrate that hypoxia regulates the metabolic state of
HSCs and protects their integrity by controlling HIF-1α.
Although hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et al. (2010) and Simsek et al. (2010) demonstrate that hypoxia regulates the metabolic state of HSCs and protects their integrity by controlling HIF-1α.
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