Maturation of dendritic cell precursors into IL12-producing DCs by J-LEAPS immunogens
PR Taylor, CC Paustian, GK Koski, DH Zimmerman… - Cellular …, 2010 - Elsevier
LEAPS (ligand epitope antigen presentation system) vaccines consist of a peptide
containing a major histocompatibility antigen binding peptide conjugated to an immune cell
binding ligand (ICBL) such as the 'J'peptide from beta-2-microglobulin. Treatment of
monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD
(containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV
p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing …
containing a major histocompatibility antigen binding peptide conjugated to an immune cell
binding ligand (ICBL) such as the 'J'peptide from beta-2-microglobulin. Treatment of
monocytes, monocytes plus GMCSF, or monocytes plus GMCSF and IL4 with JgD
(containing a peptide from gD of herpes simplex virus type 1) or JH (with a peptide from HIV
p17 gag protein) was sufficient to promote their maturation into Interleukin 12 producing …
