A-to-I RNA editing: a new regulatory mechanism of global gene expression

N Amariglio, G Rechavi - Blood Cells, Molecules, and Diseases, 2007 - Elsevier
The complexity of higher organisms is based on the number of different gene products
available for structural, regulatory and enzymatic regulatory functions and the precise and
coordinated control of gene expression. A-to-I RNA editing emerges as a global post-
transcriptional modification that affects thousands of transcripts. RNA editing is becoming a
central modification acting on double-stranded RNA and is therefore intimately associated
with other basic processes such as RNA interference, microRNA and interferon response …