[HTML][HTML] Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in vitro and in vivo
CD Andl, T Mizushima, H Nakagawa, K Oyama… - Journal of Biological …, 2003 - ASBMB
Epidermal growth factor receptor (EGFR) overexpression is observed in a number of
malignancies, especially those of esophageal squamous cell origin. However, little is known
about the biological functions of EGFR in primary esophageal squamous epithelial cells.
Using newly established primary human esophageal squamous epithelial cells as a
platform, we overexpressed EGFR through retroviral transduction and established novel
three-dimensional organotypic cultures. Additionally, EGFR was targeted in a cell type-and …
malignancies, especially those of esophageal squamous cell origin. However, little is known
about the biological functions of EGFR in primary esophageal squamous epithelial cells.
Using newly established primary human esophageal squamous epithelial cells as a
platform, we overexpressed EGFR through retroviral transduction and established novel
three-dimensional organotypic cultures. Additionally, EGFR was targeted in a cell type-and …