Uterine and circulating natural killer cells and their roles in women with recurrent pregnancy loss, implantation failure and preeclampsia

A Fukui, A Funamizu, M Yokota, K Yamada… - Journal of reproductive …, 2011 - Elsevier
The regulation of uterine and circulating peripheral blood natural killer (NK) cells has been
associated with reproductive conditions including recurrent pregnancy loss (RPL),
implantation failure and preeclampsia. Natural cytotoxicity receptors (NCRs) are unique
markers that regulate NK cell cytotoxicity and cytokine production. The role of NCRs in
reproductive events has not yet been fully characterized. There is an NK1 (Type 1) shift in
peripheral blood NK cells in non-pregnant women prone to RPL and implantation failure …