Promoter methylation in head and neck tumorigenesis
JK Stephen, KM Chen, S Havard, G Harris… - … : Methods and Protocols, 2012 - Springer
JK Stephen, KM Chen, S Havard, G Harris, MJ Worsham
Cancer Epigenetics: Methods and Protocols, 2012•SpringerIn addition to genetic alterations of gains and losses, epigenetic events of promoter
methylation appear to further undermine a destabilized genomic repertoire in squamous
head and neck carcinoma (HNSCC). This chapter provides an overview of frequently
methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC
tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck
tumorigenesis.
methylation appear to further undermine a destabilized genomic repertoire in squamous
head and neck carcinoma (HNSCC). This chapter provides an overview of frequently
methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC
tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck
tumorigenesis.
Abstract
In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.
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