The FoxO family in cardiac function and dysfunction
SM Ronnebaum, C Patterson - Annual review of physiology, 2010 - annualreviews.org
SM Ronnebaum, C Patterson
Annual review of physiology, 2010•annualreviews.orgThe Forkhead family of transcription factors mediates many aspects of physiology, including
stress response, metabolism, commitment to apoptosis, and development. The Forkhead
box subfamily O (FoxO) proteins have garnered particular interest due to their involvement in
the modulation of cardiovascular biology. In this review, we discuss the mechanisms of FoxO
regulation and outcomes of FoxO signaling under normal and pathological cardiovascular
contexts.
stress response, metabolism, commitment to apoptosis, and development. The Forkhead
box subfamily O (FoxO) proteins have garnered particular interest due to their involvement in
the modulation of cardiovascular biology. In this review, we discuss the mechanisms of FoxO
regulation and outcomes of FoxO signaling under normal and pathological cardiovascular
contexts.
The Forkhead family of transcription factors mediates many aspects of physiology, including stress response, metabolism, commitment to apoptosis, and development. The Forkhead box subfamily O (FoxO) proteins have garnered particular interest due to their involvement in the modulation of cardiovascular biology. In this review, we discuss the mechanisms of FoxO regulation and outcomes of FoxO signaling under normal and pathological cardiovascular contexts.
Annual Reviews