Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions
PJ Mohler, XHT Wehrens - Physiology, 2007 - journals.physiology.org
Physiology, 2007•journals.physiology.org
Many cardiac ion channels exist within macromolecular signaling complexes, comprised of
pore-forming subunits that associate with auxiliary subunits, regulatory enzymes, and
targeting proteins. This complex protein assembly ensures proper modulation of channel
activity and ion homeostasis. The association of genetic defects in regulatory and targeting
proteins to inherited arrhythmia syndromes has led to a better understanding of the critical
role these proteins play in ion channel modulation.
pore-forming subunits that associate with auxiliary subunits, regulatory enzymes, and
targeting proteins. This complex protein assembly ensures proper modulation of channel
activity and ion homeostasis. The association of genetic defects in regulatory and targeting
proteins to inherited arrhythmia syndromes has led to a better understanding of the critical
role these proteins play in ion channel modulation.
Many cardiac ion channels exist within macromolecular signaling complexes, comprised of pore-forming subunits that associate with auxiliary subunits, regulatory enzymes, and targeting proteins. This complex protein assembly ensures proper modulation of channel activity and ion homeostasis. The association of genetic defects in regulatory and targeting proteins to inherited arrhythmia syndromes has led to a better understanding of the critical role these proteins play in ion channel modulation.
American Physiological Society