Important immunoregulatory role of interleukin‐11 in the inflammatory process in rheumatoid arthritis
JA Hermann, MA Hall, RN Maini… - … : Official Journal of …, 1998 - Wiley Online Library
JA Hermann, MA Hall, RN Maini, M Feldmann, FM Brennan
Arthritis & Rheumatism: Official Journal of the American College …, 1998•Wiley Online LibraryObjective To investigate the possible immunoregulatory role of interleukin‐11 (IL‐11) in
rheumatoid arthritis (RA). Methods IL‐11 protein was assayed in RA tissue, and the effect of
exogenous IL‐11 on neutralization of endogenous IL‐11 was investigated with respect to
tumor necrosis factor α (TNFα), matrix metalloproteinase (MMP), and tissue inhibitor of
metalloproteinases (TIMP) production. Results IL‐11 was found in RA synovial membranes,
synovial fluids, and blood sera. Blockade of endogenous IL‐11 resulted in a 2‐fold increase …
rheumatoid arthritis (RA). Methods IL‐11 protein was assayed in RA tissue, and the effect of
exogenous IL‐11 on neutralization of endogenous IL‐11 was investigated with respect to
tumor necrosis factor α (TNFα), matrix metalloproteinase (MMP), and tissue inhibitor of
metalloproteinases (TIMP) production. Results IL‐11 was found in RA synovial membranes,
synovial fluids, and blood sera. Blockade of endogenous IL‐11 resulted in a 2‐fold increase …
Objective
To investigate the possible immunoregulatory role of interleukin‐11 (IL‐11) in rheumatoid arthritis (RA).
Methods
IL‐11 protein was assayed in RA tissue, and the effect of exogenous IL‐11 on neutralization of endogenous IL‐11 was investigated with respect to tumor necrosis factor α (TNFα), matrix metalloproteinase (MMP), and tissue inhibitor of metalloproteinases (TIMP) production.
Results
IL‐11 was found in RA synovial membranes, synovial fluids, and blood sera. Blockade of endogenous IL‐11 resulted in a 2‐fold increase in TNFα levels, which increased to 22‐fold if endogenous IL‐10 was also blocked. Addition of exogenous IL‐11 inhibited spontaneous TNFα production in RA synovium only in the presence of soluble IL‐11 receptor. However, exogenous IL‐11 directly inhibited spontaneous MMP‐1 and MMP‐3 production, and up‐regulated TIMP‐1 in RA synovial tissue.
Conclusion
IL‐11 has important endogenous immunoregulatory effects in RA synovium, which suggests that exogenous IL‐11 may have therapeutic activity in RA.
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