G/A1947 polymorphism in catechol‐O‐methyltransferase (COMT) gene in Parkinson's disease
T Xie, SL Ho, LSW Li, OCK Ma - Movement disorders: official …, 1997 - Wiley Online Library
T Xie, SL Ho, LSW Li, OCK Ma
Movement disorders: official journal of the Movement Disorder Society, 1997•Wiley Online LibraryHigh and low catechol‐O‐methyltransferase (COMT) activity is significantly determined by
thermostability, which is caused by a valine/methionine108 polymorphism associated with
polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on
this polymorphism did not find any statistically significant difference between our Chinese
Parkinson's disease and that of control subjects. These results show that this polymorphism
and hence the thermostability of COMT enzyme are not related to a risk of developing …
thermostability, which is caused by a valine/methionine108 polymorphism associated with
polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on
this polymorphism did not find any statistically significant difference between our Chinese
Parkinson's disease and that of control subjects. These results show that this polymorphism
and hence the thermostability of COMT enzyme are not related to a risk of developing …
Abstract
High and low catechol‐O‐methyltransferase (COMT) activity is significantly determined by thermostability, which is caused by a valine/methionine108 polymorphism associated with polymorphic G/A1947 bases, in exon 4 of the COMT gene. Our allelic association study on this polymorphism did not find any statistically significant difference between our Chinese Parkinson's disease and that of control subjects. These results show that this polymorphism and hence the thermostability of COMT enzyme are not related to a risk of developing Parkinson's disease.
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