Evolutionary distance from human homologs reflects allergenicity of animal food proteins
JA Jenkins, H Breiteneder, ENC Mills - Journal of Allergy and Clinical …, 2007 - Elsevier
BACKGROUND: In silico analysis of allergens can identify putative relationships among
protein sequence, structure, and allergenic properties. Such systematic analysis reveals that
most plant food allergens belong to a restricted number of protein superfamilies, with pollen
allergens behaving similarly. OBJECTIVE: We have investigated the structural relationships
of animal food allergens and their evolutionary relatedness to human homologs to define
how closely a protein must resemble a human counterpart to lose its allergenic potential …
protein sequence, structure, and allergenic properties. Such systematic analysis reveals that
most plant food allergens belong to a restricted number of protein superfamilies, with pollen
allergens behaving similarly. OBJECTIVE: We have investigated the structural relationships
of animal food allergens and their evolutionary relatedness to human homologs to define
how closely a protein must resemble a human counterpart to lose its allergenic potential …