The alternative pathway of complement activation
O Götze, HJ Müller-Eberhard - Advances in immunology, 1976 - Elsevier
Publisher Summary This chapter presents the alternative pathway of complement activation.
Two pathways for the recruitment of complement and its biological activities exist in plasma
and serum. The first is termed as the “classical pathway,” which is triggered by contact of C1
with immune complexes containing antibodies of the immunoglobulin G (IgG) or
immunoglobulin M (IgM) class. Recognition of immune complexes by C1 is followed by the
assembly of the activation unit (C2, C3, and C4) and the membrane attack unit (C5, C6, C7 …
Two pathways for the recruitment of complement and its biological activities exist in plasma
and serum. The first is termed as the “classical pathway,” which is triggered by contact of C1
with immune complexes containing antibodies of the immunoglobulin G (IgG) or
immunoglobulin M (IgM) class. Recognition of immune complexes by C1 is followed by the
assembly of the activation unit (C2, C3, and C4) and the membrane attack unit (C5, C6, C7 …
