Alterations in intracellular calcium homeostasis and cyclic adenosine 3′, 5′-phosphate
likely underlie the increased cell proliferation and fluid secretion in polycystic kidney
disease. Hormone receptors that affect cyclic adenosine 3′, 5′-phosphate and are
preferentially expressed in affected tissues are logical treatment targets. There is a sound
rationale for considering the arginine vasopressin V2 receptor as a target. The arginine
vasopressin V2 receptor antagonists OPC-31260 and tolvaptan inhibit the development of …