[HTML][HTML] Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alpha
AJ Groot, P Verheesen, EJ Westerlaken, EH Gort… - Laboratory …, 2006 - Elsevier
Hypoxia triggers the transcription of genes responsible for cell survival via the key player
transcription factor hypoxia-inducible factor 1alpha (HIF-1α). Overexpression of this protein
has been implicated in cardiovascular disorders, carcinogenesis and cancer progression.
For functional and diagnostic studies on the HIF-1α protein, we have identified single-
domain antibody fragments directed against this protein by using a llama-derived
nonimmune phage display library. This library displays the variable domains of the heavy …
transcription factor hypoxia-inducible factor 1alpha (HIF-1α). Overexpression of this protein
has been implicated in cardiovascular disorders, carcinogenesis and cancer progression.
For functional and diagnostic studies on the HIF-1α protein, we have identified single-
domain antibody fragments directed against this protein by using a llama-derived
nonimmune phage display library. This library displays the variable domains of the heavy …
