[HTML][HTML] Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors
P Sacchetti, H Dwornik, P Formstecher… - Journal of Biological …, 2002 - ASBMB
The nuclear receptor nurr1 is a transcription factor involved in the development and
maintenance of neurons synthesizing the neurotransmitter dopamine. Although the lack of
nurr1 expression has dramatic consequences for these cells either in terms of differentiation
or survival, the mechanisms by which nurr1 controls gene transcription still remain unclear.
In the intent to understand better the modalities of action of this nuclear receptor, we have
undertaken a systematic analysis of the transcriptional effects and DNA binding properties of …
maintenance of neurons synthesizing the neurotransmitter dopamine. Although the lack of
nurr1 expression has dramatic consequences for these cells either in terms of differentiation
or survival, the mechanisms by which nurr1 controls gene transcription still remain unclear.
In the intent to understand better the modalities of action of this nuclear receptor, we have
undertaken a systematic analysis of the transcriptional effects and DNA binding properties of …
