[HTML][HTML] Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction
M Ohtsuki, Y Taketomi, S Arata, S Masuda… - Journal of biological …, 2006 - ASBMB
In an effort to elucidate the functions of secreted phospholipase A 2 (sPLA 2) enzymes in
vivo, we generated transgenic (Tg) mice for group V sPLA 2 (sPLA 2-V) and group X sPLA 2
(sPLA 2-X), which act potently on phosphatidylcholine in vitro. We found that sPLA 2-V Tg
mice died in the neonatal period because of respiratory failure. The lungs of sPLA 2-V Tg
mice exhibited atelectasis with thickened alveolar walls and narrow air spaces,
accompanied by infiltration of macrophages and only modest changes in eicosanoid levels …
vivo, we generated transgenic (Tg) mice for group V sPLA 2 (sPLA 2-V) and group X sPLA 2
(sPLA 2-X), which act potently on phosphatidylcholine in vitro. We found that sPLA 2-V Tg
mice died in the neonatal period because of respiratory failure. The lungs of sPLA 2-V Tg
mice exhibited atelectasis with thickened alveolar walls and narrow air spaces,
accompanied by infiltration of macrophages and only modest changes in eicosanoid levels …
