DNA methylation in health and disease
KD Robertson, AP Wolffe - Nature reviews genetics, 2000 - nature.com
KD Robertson, AP Wolffe
Nature reviews genetics, 2000•nature.comDNA methylation has recently moved to centre stage in the aetiology of human
neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These
diseases result from the misregulation of genes that occurs with the loss of appropriate
epigenetic controls during neuronal development. Recent advances have connected DNA
methylation to chromatin-remodelling enzymes, and understanding this link will be central to
the design of new therapeutic tools.
neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These
diseases result from the misregulation of genes that occurs with the loss of appropriate
epigenetic controls during neuronal development. Recent advances have connected DNA
methylation to chromatin-remodelling enzymes, and understanding this link will be central to
the design of new therapeutic tools.
Abstract
DNA methylation has recently moved to centre stage in the aetiology of human neurodevelopmental syndromes such as the fragile X, ICF and Rett syndromes. These diseases result from the misregulation of genes that occurs with the loss of appropriate epigenetic controls during neuronal development. Recent advances have connected DNA methylation to chromatin-remodelling enzymes, and understanding this link will be central to the design of new therapeutic tools.
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