Leptin signaling
RS Ahima, SY Osei - Physiology & behavior, 2004 - Elsevier
RS Ahima, SY Osei
Physiology & behavior, 2004•ElsevierThe discovery of leptin was a major breakthrough in our understanding of the role of adipose
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent
obesity; however, studies have demonstrated profound effects of leptin in the response to
fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain
development. This review will focus on the signaling pathways which mediate these diverse
effects of leptin in the brain and other physiologic systems.
tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent
obesity; however, studies have demonstrated profound effects of leptin in the response to
fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain
development. This review will focus on the signaling pathways which mediate these diverse
effects of leptin in the brain and other physiologic systems.
The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.
Elsevier