[HTML][HTML] Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
In mammals, nic o tin a mide phosphoribosyltransferase (NAMPT) and nic o tin a mide
mononucleotide ad en y lyltransferase 1 (NMNAT-1) constitute a nuclear NAD+ salvage
pathway which regulates the functions of NAD+-de pend ent enzymes such as the protein
deacetylase SIRT1. One of the major functions of SIRT1 is to regulate target gene
transcription through modification of chromatin-associated proteins. However, little is known
about the molecular mechanisms by which NAD+ biosynthetic enzymes regulate SIRT1 …
mononucleotide ad en y lyltransferase 1 (NMNAT-1) constitute a nuclear NAD+ salvage
pathway which regulates the functions of NAD+-de pend ent enzymes such as the protein
deacetylase SIRT1. One of the major functions of SIRT1 is to regulate target gene
transcription through modification of chromatin-associated proteins. However, little is known
about the molecular mechanisms by which NAD+ biosynthetic enzymes regulate SIRT1 …