[HTML][HTML] SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
X Hou, S Xu, KA Maitland-Toolan, K Sato… - Journal of Biological …, 2008 - ASBMB
Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase.
Because we have recently defined AMPK activation as a key mechanism for the beneficial
effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in
type 1 diabetic mice, we hypothesize that polyphenol-activated SIRT1 acts upstream of
AMPK signaling and hepatocellular lipid metabolism. Here we show that polyphenols,
including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase …
Because we have recently defined AMPK activation as a key mechanism for the beneficial
effects of polyphenols on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in
type 1 diabetic mice, we hypothesize that polyphenol-activated SIRT1 acts upstream of
AMPK signaling and hepatocellular lipid metabolism. Here we show that polyphenols,
including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase …