[HTML][HTML] Interleukin 1 activates STAT3/nuclear factor-κB cross-talk via a unique TRAF6-and p65-dependent mechanism
Y Yoshida, A Kumar, Y Koyama, H Peng… - Journal of Biological …, 2004 - ASBMB
Interleukins (IL) 1 and 6 are important cytokines that function via the activation, respectively,
of the transcription factors NF-κB and STAT3. We have observed that a specific type of κB
DNA sequence motif supports both NF-κB p65 homodimer binding and cooperativity with
non-tyrosine-phosphorylated STAT3. This activity, in contrast to that mediated by κB DNA
motifs that do not efficiently bind p65 homodimers, is shown to be uniquely dependent upon
signal transduction through the carboxyl terminus of TRAF6. Furthermore, STAT3 and p65 …
of the transcription factors NF-κB and STAT3. We have observed that a specific type of κB
DNA sequence motif supports both NF-κB p65 homodimer binding and cooperativity with
non-tyrosine-phosphorylated STAT3. This activity, in contrast to that mediated by κB DNA
motifs that do not efficiently bind p65 homodimers, is shown to be uniquely dependent upon
signal transduction through the carboxyl terminus of TRAF6. Furthermore, STAT3 and p65 …
